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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '220da8d1794efad8d419cb731d494ae5a40bdc40488868272f63095ef7fc6367' 
  AND token = 'uOftpemXsXjutlmuzb866y6OfbohLL+4nDsTsKO61H8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}