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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72a853115d83cf335836c3fb91c0c6be57820185e11e0203bafcb1e445c6fa66' 
  AND token = 'caP0+j9ZJilWE4xKOgPrrkWCqX28tRlImSaNyd4qxMw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}