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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50615d4c761aae52ec4973e0eeb77b448ddef464b3ac1ca4c2af6910637345f4' 
  AND token = 'S5TFzreqry+EkeXQW08RrTp8sDTquwBIz+gbIibE6a0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}