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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '501f8490fae68a93a80a22641c29224dc6a8bcd093cad5a8ed1e949eb6d2d5f7' 
  AND token = '0W+1Rn6fTSVCDRRsgMGk2HiKe32kV7nV3fRqMAWLY10=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}