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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53b5a51e6516352d3ae05befbcc7d0f21db199e6823b12b8d727dbc92d8720e1' 
  AND token = 'YxSNJV0AEu6qevWvdXa/FFScVIGqfBf2gsjPmrq+SKo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}