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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44c3f500c0a1218e04b0d35f3258ea3577d9710b09b8f90b4077297e9a588931' 
  AND token = 'xvgo9R+DKt0fotOO4UxraYapmDQnnHoHuPEROEYn0xM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}