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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd4208e7ff85c904dccd72474e2f00ff61bd8fc380da60f501d4aef584de56457' 
  AND token = 'jWMYY20FAbYRvyHEiNDriqo5bOoH1E6OF4axlGGcCf4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}