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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb4e27df45b55f709492453d4f18b8f2952a1537fe9b0aede463ffdb66fdab11' 
  AND token = 'Xyu20NN9ntz/FHQ+RZfE3D5jyV3Qg4r8QUYPZHNqCfs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}