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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c81d3c8cf7027961106f3c6f9bd103b24483b53f7146f26ebe14b3ada1e3bdff' 
  AND token = 'p00NN4BykHFOGKqV/CgeJ+7BS2gqb010+LyN+Cbe7S4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}