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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2450a597dd04a669a6100f95a83f7f4e2a4b9d491144974e54333df752a8774' 
  AND token = 'VdNUDfwhehcXgNwjf+a17/4lZAKEnXTcGnGDQGteI0E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}