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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '29bc01da8d3d71d2d73e4d71bbcd9c50746cd96fd219a64858fe25aa322aca2b' 
  AND token = 'qqEF1Cvb/8nMaBdu4CA9opeRhlrSoUeHcak7ygEEVW8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}