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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bef3b9fbc648f06bf9033c354ee61f04b27712b97d4d5814261ed4242ef66b11' 
  AND token = 'B9DAtXdX3opb4+UCGbwpWUAE6VmCE8VAwHR6+Swiuzk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}