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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3a66babd55c3e69dbd850a873b1c65d99b6a222f6f00f32233d28a02fa3e7620' 
  AND token = 'X75dXPWiDW2fdjUl/CehyfdtG7f5gIMUkiBbzaBntl4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}