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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e0044c2d9b284ab36d76a1afe322b19f886b60d1c9c02256a7eecbbb74508a1' 
  AND token = 'CpUR9nMaRGlbk5fjAO+hKNXcDpwSqA5IzRu4BsGnFpI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}