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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5c1f729952e0bbf2382dd2db0fbffcf4b40c68965cb7b011160cd876b56ac0c6' 
  AND token = 'xV3xJT1rCFI5g+vmYPbXZa5zaVgwzm7EgR0vMjF87Xs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}