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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'eafc43b481cf08135b17cf39c442d1fcda4d7cd51f75f72a9cce0304ed35e32f' 
  AND token = 'Zk/vn0EdX2QjQIaaAs8+161BZQtMA5/iY3SM7Pd3FBE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}