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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22ce6e33a26a0504e251b8210a48afb5f3a76f598be9ca5c369c01c492097c3a' 
  AND token = 'Lj+s5NRQ0ICEIcwKKkh5in3D7WbubT+LoAx3pgmPwOM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}