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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43c16e96c9a2bd8446fa10caded7d780f7250f98ee2fd85df1679ffac1e12e5d' 
  AND token = 'QiUtkaIlgMJtxIBy8WOhrCixnHXP2TsfzQ0tgIeLan0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}