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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e790537cbb310a04e2547f3ec8475863d002fad3f35dbf4d80d3a3d3e2f1fa1' 
  AND token = 'pYjv076rY+BAFVb5K3wQGn/QUTKeXEcks6QxGC3aXWg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}