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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '259fd9b112c453417b5f293b33adf2094110b15b2dea3e71608e135b8da25843' 
  AND token = 'dI/i8tZdQIoAgjlVZw+qADBI3aPQOZpT5AG0C3zOB9I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}