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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e758bfe8b01d93411614bd4f4488a6dc16125cb72e52a15a54365e1014921540' 
  AND token = 'panhWcPnc7Ys/YCgsIU/oYpJKu0APiy7N2hNYtsZRB4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}