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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f868368806e0f35dccd18cc778a4dc78fcea5272580a4529a2632f50c779fbbe' 
  AND token = 'eJmDj7PhpuTedgULxTyDlIkjUVakCUvmWusNxjox2dI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}