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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f21dc13df3a70de9bb0a206a75552cdd0a17b5a5906e6f10949bd868d523a71' 
  AND token = '7usMrEcMuZ7MgHsahmYwQWUuOqKIc0iuQv/Ogpw+Y6A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}