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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0ff286620fd51f33dce234499abf04cd1a0678393ea227f9f9de57be24801f00' 
  AND token = 'KHKXOsTB3ep/AF1XODqzabrMyItt6GhhieH/ryCP3wQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}