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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50597a9f358753d8b9f309d2a243feb63881f3f0a9e5616c5ef7e099c44d3346' 
  AND token = 'yDTfU6lHEDUBxf5idOEZZBMF7Gvn4bt/FJTKGLcthcw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}