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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd21733fc07fd5e1470481aa812374b5d06e42a6d859873376748d452d0f2cf0a' 
  AND token = 'syv/C8jUa22Q1Dp7lMPy0WS9BPISdrT4PVWJYU551vk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}