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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '643c50cf71f7450343e3fb44bde8f697e40e48b0efecc6986a29f42322785c7f' 
  AND token = 'iS/tXB1fIBA4EwH5oeSX2egY+rgfjQcmKE0Zt8TD9RY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}