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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd297c3e4deccd7682a00163a6219ac8ebfab8c0775f732c8eede46cfd7e5cf80' 
  AND token = 'S8XdEdImB77msZTIvg5kfOyo7l/hJDI91G1Gd6aiLUw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}