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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '556b99a05297623dd36b807fa100a9dce1ad01a502d8e2a2f7bfdc3ad5105d0b' 
  AND token = 'SHTb34SLbeWoDAngYDjC6OfvfhxtifV9GYHuDEn4Z5E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}