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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3fe2ecd023bbe0966d3ff1a063c0d5c0c961a4e4e693e58e083391df3def5f49' 
  AND token = 'CXBMIG3jzUeW4ypuFHKYe/CzznXcbsJG+3wsUFIpn4U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}