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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f646aa88fc7295ff8e6c2fb9e35a90e3f700e36761c710aad5c13d6b48855bfa' 
  AND token = 'oPgaZt3DaqrQwgRS2PBonIkXHHa+gNZokhfxwujjJLo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}