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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e5436ea7f092318841a6c1cac247320fe664c51d35c698a87c927ab8f0fee187' 
  AND token = 'edk3fwVAJwENcmpx7knj9FrOph65f0WX++661Ig15P8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}