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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd571322bec81d8b5532ca179c7d66cbb014a45c9a6c4072fdacfee9384037f65' 
  AND token = 'ApbfPP0PVhlas8LZmKFz25148GXRkPt1tg05rAaE6tM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}