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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '278dbcb25fd01439e7f82fa2fac5ea5714597f8c1e09c6574f98dc30b315d424' 
  AND token = 'DkgU78GPqs83p60JQG3KkKlKGBA5Sbj6Icb++0Rf+ZI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}