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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48e5734e8e506bf88e7933b3e013e5106b77cf930bc78806dab6fce80ad7c915' 
  AND token = '72w9RvHyAQaEOblEovKRwUc8nlmqrK11bqcKmsmG6qI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}