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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d01652d19eab2333aff895d81d9bc7a08cf1e86a60c0c65dfe1856527e60c51' 
  AND token = 'r/Zqdhehb+9h8TE4TGk+Calcb2ka/75CxDmAmoYeRV4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}