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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '815abb21cc2eda2a5b558909baf7b6cc5d405e5f0257e869a630a120da5630c5' 
  AND token = 'DnoXLtLnMc9IROHLcwJGjB2rkK6SxLG/wp52IOThXhk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}