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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21863d02909955d0c4f03ef0dc35a869727b86a3dba1a63acab218fd42be646a' 
  AND token = '6tyXgLE1iP2hR+0zV8PcyRUY1GSiR1fFx/m5qtHTT+o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}