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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd5341bb59117702e61d30a956d70b9644ef6e69f557690e1292e58f53231633f' 
  AND token = 'mAdBLDzIttdXyp+48a2BYq0zOXfLK8KfC6IW4DpLGOI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}