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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b42b5dcdff963e401bc59e29b0d02d439b9469fa6312a96c11a30db8c42af0af' 
  AND token = 'p78WfVR2YI6nE0WmhomkvRXUTo3X9i4+oXnh3ZTZUyU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}