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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57194577b0f09962d963e1c864dcf3fef09156029e6b2f51ee54a48feeee186a' 
  AND token = 'r/G301zdZJHZp0EdGKWvDtRXiwC2sJZI8h0MQim7EiI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}