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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de2ef4f6e15c0c5e06d023ead5d2fd58749d06d0abf76231ccffbe578e199f95' 
  AND token = 'LC00LqFQOayQ45PlEZmIzb+bPfAp8CAIlcUvAZQ2sGY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}