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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e0036181ba21e80385b3a410393a4d15047c679df0987c34fd04014b48baea7' 
  AND token = 'adP17xMbQvUifz8tfKvataSZ3DQh5DnoC24RnlZd0Wk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}