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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49dc24291585ddc32d4039f3a233218d52fd8beb7fc240dbc3c33cdab08e7204' 
  AND token = 'aSL/m0E4z9mMulPJrswTmSC5/g7vLm8rXKodzDSxAgQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}