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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65b2c935d042a07d920eff8d5e49727d1d91721dd5e33d47a12ef6047f53651c' 
  AND token = '16Egmr/JqnZ3cAl8WwWSQj0oXWTo5DZOJ+uAo3+84kc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}