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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6579fe9d76d3a3e7f31da48f1d6e02f54d28a3763deb0f1bebc2fe3e68edc145' 
  AND token = 'iHQFn473Dpqn9zWqyYX6mSCRLgHfvBnAFS9PQc7FZiU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}