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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed2d2ac72f6385c0d2ae788f146d14352604ce181414afb7d1defa7d1fe3506a' 
  AND token = 'EA4qsvG2eMhEWqRNnAJoQDlEPZNaBFkk0+ikoSu2Z5w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}