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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4143d9b41fe96a297fe875da07bb5aec022f019b1d15206d2c2fbdbbb73c1360' 
  AND token = 'eSCn+WCMlF7pVu9U95jg5/Rpi0/UrMVm6ugo9Juf+DE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}