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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22fdd8789feb77196e4598f2a77504b47f87c91c452b50046c7a21f72a87924f' 
  AND token = 'pZm3GZra07ANn4FIhUCQnByCH9C+4/aogkTrsetcQ3Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}