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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22b28040d5e0ca66907cdabbb6b40c9c75ca6d28371a9931f29f5836b83ed2d6' 
  AND token = 'tvkIX6TE9boRR5KFy302be7AeUeYbgjd2MidUdVOTkg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}